Specific CD8+T cells recognize human herpesvirus 6B
نویسندگان
چکیده
منابع مشابه
Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A.
Human herpesvirus 6 variants A and B (HHV-6A and HHV-6B) are closely related viruses that can be readily distinguished by comparison of restriction endonuclease profiles and nucleotide sequences. The viruses are similar with respect to genomic and genetic organization, and their genomes cross-hybridize extensively, but they differ in biological and epidemiologic features. Differences include in...
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BACKGROUND Human herpesvirus-6 (HHV-6) is a beta-herpesvirus with 90% seroprevalence that infects and establishes latency in the central nervous system. Two HHV-6 variants are known: HHV-6A and HHV-6B. Active infection or reactivation of HHV-6 in the brain is associated with neurological disorders, including epilepsy, encephalitis, and multiple sclerosis. In a preliminary study, we found HHV-6B...
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The aim of the present study was to assess the frequency of human herpesvirus 6A (HHV-6A) and human herpesvirus 6B (HHV-6B) infection during pregnancy. 100-100 blood samples were collected from pregnant and non-pregnant women, then nucleic acid was isolated from both plasma and leukocytes fraction. Nested and real-time PCR were used to detect and differentiate HHV-6A and HHV-6B DNA and to deter...
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Background. Human herpesvirus 6B (HHV-6B) is the causative agent for exanthema subitum. This virus has been suggested to have neurovirulence based on the in-vivo and in-vitro studies. HHV-6B has been suggested to be associated with mesial temporal sclerosis (MTS) that results in mesial temporal lobe epilepsy. Aims of this study was to elucidate pathogenic role of HHV-6B in patients with MTS. Me...
متن کاملCrystal Structure of Human Herpesvirus 6B Tegument Protein U14
The tegument protein U14 of human herpesvirus 6B (HHV-6B) constitutes the viral virion structure and is essential for viral growth. To define the characteristics and functions of U14, we determined the crystal structure of the N-terminal domain of HHV-6B U14 (U14-NTD) at 1.85 Å resolution. U14-NTD forms an elongated helix-rich fold with a protruding β hairpin. U14-NTD exists as a dimer exhibiti...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2012
ISSN: 0014-2980
DOI: 10.1002/eji.201242439